Part One
Organization of the Body 1
Chapter 1
Major Themes of Anatomy and Physiology 1
The Scope of Anatomy and Physiology 2
The Origins of Biomedical Science 3
Scientific Method 7
Human Evolution 9
The Nature of Human Life 12
Homeostasis and Feedback 19
Review of Major Themes 21
Chapter Review 25
Atlas A
General Orientation to Human Anatomy 28
Anatomical Position 29
Anatomical Planes 30
Directional Terms 31
Surface Anatomy 31
Body Cavities and Membranes 35
Organ Systems 38
A Visual Survey of the Body 38
Testing Your Recall 50
Testing Your Comprehension 50
Chapter 2
Matter and Energy 51
Chemical Elements and Atomic Structure 52
Molecules, Compounds, and Chemical Bonds 57
Mixtures 60
Acids, Bases, and pH 63
Chemical Reactions 65
Energy and Metabolism 67
Ionizing Radiation 69
Chapter Review 71
Chapter 3
The Molecules of Life 76
Inorganic Molecules 77
Carbon and Organic Molecules 79
Carbohydrates 81
Lipids 85
Proteins 87
Enzymes and Metabolism 93
Nucleotides and Nucleic Acids 96
Chapter Review 100
Chapter 4
Cellular Form and Function 103
Concepts of Cellular Structure 104
The Cell Surface 108
The Cytoplasm 116
Membrane Transport I: Filtration and Simple Diffusion 123
Membrane Transport II: Carrier-Mediated and Bulk Transport 128
Chapter Review 137
Chapter 5
Genetics and Cellular Function 140
The Nucleus and Nucleic Acids 141
Protein Synthesis and Secretion 146
DNA Replication and the Cell Cycle 153
Chromosomes and Heredity 159
Chapter Review 168
Chapter 6
Histology 171
The Study of Tissues 172
Epithelial Tissue 174
Connective Tissue 180
Nervous and Muscular Tissue-Excitable Tissues 190
Intercellular Junctions, Glands, and Membranes 191
Tissue Growth, Development, Death, and Repair 197
Chapter Review 201
Part Two
Support and Movement 205
Chapter 7
The Integumentary System 205
Structure of the Skin and Subcutaneous Tissue 206
Functions of the Skin 213
Hair and Nails 214
Cutaneous Glands 220
Diseases of the Skin 222
Connective Issues 227
Chapter Review 228
Chapter 8
Bone Tissue 231
Tissues and Organs of the Skeletal System 232
Histology of Osseous Tissue 235
Bone Development 240
Physiology of Osseous Tissue 243
Bone Disorders 248
Chapter Review 254
Chapter 9
The Skeletal System 257
Overview of the Skeleton 258
The Skull 260
The Vertebral Column and Thoracic Cage 275
The Pectoral Girdle and Upper Limb 285
The Pelvic Girdle and Lower Limb 293
Connective Issues 303
Chapter Review 304
Chapter 10
Joints 307
Joints and Their Classification 308
Fibrous, Cartilaginous, and Bony Joints 309
Synovial Joints 312
Anatomy of Selected Diarthroses 323
Chapter Review 336
Chapter 11
The Muscular System 339
The Structural and Functional Organization of Muscles 340
Muscles of the Head and Neck 348
Muscles of the Trunk 359
Muscles Acting on the Shoulder and Upper Limb 370
Muscles Acting on the Hip and Lower Limb 386
Connective Issues 401
Chapter Review 402
Atlas B
Surface Anatomy 404
The Importance of External Anatomy 405
Head and Neck 406
Trunk 407
Upper Limb 410
Lower Limb 412
Muscle Self-Testing Exercise 418
Chapter 12
Muscular Tissue 419
Types and Characteristics of Muscle Tissue 420
Microscopic Anatomy of Skeletal Muscle 421
The Nerve-Muscle Relationship 424
Behavior of Skeletal Muscle Fibers 429
Behavior of Whole Muscles 436
Muscle Metabolism 439
Cardiac and Smooth Muscle 444
Chapter Review 450
Part Three
Integration and Control 453
Chapter 13
Nervous Tissue 453
Overview of the Nervous System 454
Cells of the Nervous System 456
Electrophysiology of Neurons 463
Synapses 472
Neural Integration 478
Chapter Review 486
Chapter 14
The Central Nervous System 490
Overview of the Central Nervous System 491
Meninges, Ventricles, Cerebrospinal Fluid, and Blood Supply 496
The Spinal Cord 501
The Hindbrain and Midbrain 507
The Forebrain 512
Higher Brain Functions 519
Chapter Review 533
Chapter 15
The Peripheral Nervous System and Reflexes 537
General Anatomy of the Peripheral Nervous System 538
The Cranial Nerves 541
The Spinal Nerves 550
Somatic Reflexes 562
The Autonomic Nervous System: Introduction and Anatomy 568
The Autonomic Nervous System: Physiology 577
Connective Issues 583
Chapter Review 584
Chapter 16
Sense Organs 587
Properties and Types of Sensory Receptors 588
The General Senses 589
The Chemical Senses 593
Hearing and Equilibrium 599
Vision 611
Chapter Review 633
Chapter 17
The Endocrine System 637
Overview of the Endocrine System 638
The Hypothalamus and Pituitary Gland 640
Other Endocrine Glands 648
Hormones and Their Actions 661
Stress and Adaptation 670
Eicosanoids and Other Chemical Messengers 671
Connective Issues 675
Chapter Review 676
Part Four
Regulation and Maintenance 680
Chapter 18
The Circulatory System: Blood 680
Functions and Properties of Blood 681
Plasma 683
Blood Cell Production 686
Erythrocytes 690
Blood Types 696
Leukocytes 700
Hemostasis-The Control of Bleeding 704
Chapter Review 712
Chapter 19
The Circulatory System: The Heart 715
Gross Anatomy of the Heart 716
Cardiac Muscle and the Cardiac Conduction System 726
Electrical and Contractile Activity of the Heart 729
Blood Flow, Heart Sounds, and the Cardiac Cycle 733
Cardiac Output 739
Chapter Review 745
Chapter 20
The Circulatory System: Blood Vessels and Circulation 749
General Anatomy of the Blood Vessels 750
Blood Pressure, Resistance, and Flow 756
Capillary Exchange 763
Venous Return and Circulatory Shock 766
Special Circulatory Routes 769
Anatomy of the Pulmonary Circuit 770
Anatomy of the Systemic Arteries 770
Anatomy of the Systemic Veins 786
Connective Issues 797
Chapter Review 798
Chapter 21
The Lymphatic and Immune Systems 802
The Lymphatic System 803
Nonspecific Resistance 811
General Aspects of Specific Immunity 819
Humoral Immunity 823
Cellular Immunity 827
Immune System Disorders 832
Connective Issues 838
Chapter Review 839
Chapter 22
The Respiratory System 843
Anatomy of the Respiratory System 844
Mechanics of Ventilation 854
Neural Control of Ventilation 860
Gas Exchange and Transport 862
Blood Chemistry and the Respiratory Rhythm 870
Respiratory Disorders 871
Connective Issues 876
Chapter Review 877
Chapter 23
The Urinary System 881
Functions of the Urinary System 882
Anatomy of the Kidney 883
Urine Formation I: Glomerular Filtration 888
Urine Formation II: Tubular Reabsorption and Secretion 894
Urine Formation III: Water Conservation 898
Urine and Renal Function Tests 901
Urine Storage and Elimination 904
Connective Issues 910
Chapter Review 911
Chapter 24
Water, Electrolyte, and Acid-Base Balance 915
Water Balance 916
Electrolyte Balance 922
Acid-Base Balance 927
Chapter Review 935
Chapter 25
The Digestive System 938
General Anatomy and Digestive Processes 939
The Mouth Through Esophagus 941
The Stomach 949
The Liver, Gallbladder, and Pancreas 958
The Small Intestine 964
Chemical Digestion and Absorption 968
The Large Intestine 974
Connective Issues 980
Chapter Review 981
Chapter 26
Nutrition and Metabolism 984
Nutrition 985
Carbohydrate Metabolism 995
Lipid and Protein Metabolism 1004
Metabolic States and Metabolic Rate 1006
Body Heat and Thermoregulation 1009
Chapter Review 1013
Part Five
Reproduction and Development 1016
Chapter 27
The Male Reproductive System 1016
Sexual Reproduction 1017
Sex Determination and Development 1018
Male Reproductive Anatomy 1022
Puberty and Climacteric 1030
Spermatogenesis, Spermatozoa, and Semen 1031
Male Sexual Response 1037
Chapter Review 1043
Chapter 28
The Female Reproductive System 1046
Reproductive Anatomy 1047
Puberty and Menopause 1056
Oogenesis and the Sexual Cycle 1058
Female Sexual Response 1065
Pregnancy and Childbirth 1067
Lactation 1074
Connective Issues 1080
Chapter Review 1079
Chapter 29
Human Development 1084
Fertilization and Preembryonic Development 1085
Embryonic and Fetal Development 1090
The Neonate 1096
Aging and Senescence 1103
Chapter Review 1113
Appendix A: Periodic Table of the Elements A-1
Appendix B: Answers to Testing Your Recall Questions A-2
Appendix C: Understanding Biomedical Vocabulary A-6