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Schizophrenia
is sometimes treated with drugs such as chlorpromazine that inhibit dopamine
receptors. A side effect is that patients begin to develop muscle tremors, speech
impairment, and other disorders characteristic of Parkinson disease. Explain.
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Hyperkalemia is a condition in which
there is excess K+ in the extracellular fluids. What effect would
this have on the resting membrane potentials of the nervous system and on neuronal
excitability?
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Suppose the sodium-potassium pumps of nerve cells were to slow down because of some metabolic disorder. How would this affect the resting membrane potentials of neurons? Would it make neurons more excitable than normal, or make them more difficult to stimulate? Explain.
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- The unity of form and function is an important
concept in understanding synapses. Give two structural reasons why nerve signals
cannot travel backward across a synapse. What might the consequences be if
they did travel freely in both directions?
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The local anesthetics procaine (Novocain)
and tetracaine prevent voltage-regulated Na+ gates from opening.
Explain why this would block the conduction of pain signals in a sensory nerve.
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