Hematology Case Histories - Case 10

A 62-year-old male complained of weakness, headache, light-headedness, and fatigue. Upon physical examination, the following information was available:

Erythrocytes 8.5 million/cu mm
Leukocytes 12,500/cu mm
Thrombocytes 400,000/cu mm
Hct 58%
O2 saturation (arterial) 94%
Serum erythropoietin Undetectable

The erythrocytes and leukocytes were immature in the peripheral blood smear. The spleen was enlarged. The determined therapy of choice was phlebotomy, 300-500 mL every other day, until the hematocrit was <45% with the possibility of myelosuppressive therapy, if needed.

1. What is the disorder of this individual?

2. Why are the arterial O2 saturation and erythropoietin levels important in making this decision?

3. Define phlebotomy.

4. How does phlebotomy help correct this problem?

5. Define myelosuppressive therapy.

6. Why may myelosuppressive therapy be needed?

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