Activities and Tutorials

The following sites provide you with tutorials, information-gathering opportunities, and/or interactive exercises focusing on the concepts covered in each chapter.

• Morgan Tutorial Level 1: This tutorial will introduce you to the fundamental concepts of genetics.

Chapter 2

• Examine cell composition at CellsAlive! and the Virtual Cell.

• The Studying Cells Problem Set and Tutorial at The Biology Project will help you to review the basic principles covered in this chapter.

• The Cytoskeleton Tutorial and Problem Set at The Biology Project will also help you to review the basic principles covered in this chapter.

• Mitosis and the cell cycle tutorials

• You can easily access specific information about adrenoleukodystrophy, cystic fibrosis, neurofibromatosis, Wilson disease, Zellweger syndrome, and muscular dystrophy through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about Lesh-Nyhan syndrome, hypercholesterolemia, maple syrup urine disease, and/or biotinidase deficiency.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 3

• Examine male and female genital tract pathology at this pathology website.

• Meiosis Tutorials

• Prenatal Development Informational Sites

• The Pregnancy Calculator calculates a due date given the date of the last menstrual cycle or date of conception.

• How prevalent are genetic conditions and birth defects? This site from the University of Kansas Medical Center provides you with statistics and references.

• The Roslin Institute Home Page contains information about nuclear transfer, the technique used to clone dolly.

• Clones-R-Us: Looking for a company to create your next clone? Consider Dream Technologies International.

• You can easily access specific information about Alzheimer disease, apolipoprotein E, and Werner Syndrome through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about osteogenesis imperfecta, Alzheimer disease, and/or progeria.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 4

• Morgan Level 2: This tutorial will introduce you to the concepts of alleles and mutations.

• Review the relationship between meiosis and Mendelian segregation with this Meiosis and Mendelian Genetics Tutorial.

• The Mendelian Genetics Problem Sets and Tutorial at The Biology Project will help you learn about the basic principles that govern Mendelian inheritance. In this tutorial, you can practice solving monohybrid and dihybrid problems.

• Human Genetics at The Biology Project will help you to learn about constructing pedigrees.

• The Human Genetics Problem Set at The Biology Project will also help you to review the basic principles covered in this chapter.

• MIT Biology Hypertextbook: Review the basic concepts of Mendelian genetics by studying this chapter of the MIT Biology Hypertextbook.

• You can easily access specific information about cystic fibrosis and Huntington disease through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about distal symphalangism, albinism, xeroderma pigmentosum, and/ or sickle cell anemia.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 5

• Human Blood Types at The Biology Project will help you learn about the inheritance of human blood types and Rh factors as well as the usefulness of this information in paternity cases.

• Morgan Tutorial Level 4: This tutorial will introduce you to the concept of linked genes.

• Morgan Tutorial Level 5: This tutorial will introduce you to the concept recombination.

• MIT Biology Hypertextbook: Review linkage mapping by studying this chapter of the MIT Biology Hypertextbook.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about polydactyly, porphyria, Prader-Willi syndrome, Angelman syndrome, and/or nail-patella.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 6

• Sex Linkage Problem Sets and Tutorials from The Biology Project will help you to learn about the principle that govern the inheritance of genes located on the sex chromosomes.

• Morgan Tutorial Level 6: This tutorial will help you to understand the role of the sex chromosomes in sex determination.

• MIT Biology Hypertextbook: Review the principles that govern the inheritance of sex linked traits by studying the sex-linkage section of the MIT Biology Hypertextbook.

• Chapter 20 of Zygote focuses on sex determination during human embryonic development.

• How has the ratio of males to females changed over the past 200 years? This animation will answer the question.

• You can easily access specific information long QT syndrome and Menkes syndrome through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about ichthyosis, hemophilia, color-blindness, and/or hypertrichosis.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 7

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about cystic fibrosis, neural tube defects, intelligence, narcolepsy, schizophrenia, alcoholism, and/or bipolar affective disorder.

• You can easily access specific information about obesity through the Human Gene Map Site.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 8

• Learn about the DNA basics by exploring DNA from the Beginning.

• Test your ability to identify nucleotides with this quiz.

• A Science Odyssey: You Try It from PBS Online has an interactive activity on DNA replication and gene expression.

• MIT Biology Hypertextbook: Review nucleic acid chemistry by studying this chapter of the MIT Biology Hypertextbook.

• If you are using Netscape 3.01 or 4.01 and you download the Chemscape Chime plug-in, you can view interactive 3-D structures of DNA and RNA structure. Quizzes that challenge you to identify nucleotides or amino acids are also available at this site.

• You can easily access specific information ataxia telangiectasia and colon cancer through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about atexia telangiectasis, Bloom syndrome, Fanconi anemia, nonpolyposis colon cancer, and/or xeroderma pigmentosum.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 9

• Eukaryotic Gene Expression from The Biology Project will help you learn about gene expression.

• A Science Odyssey: You Try It from PBS Online has an interactive activity on DNA replication and gene expression.

• MIT Biology Hypertextbook: Review the genetic code and transcription by studying this chapter of the MIT Biology Hypertextbook.

• Primer on Molecular Genetics: Review the techniques and application of molecular genetics at this site by the Department of Energy.

• Visit the Genetic Code Viewer to examine the genetic codes of a variety of organisms.

• If you are using Netscape 3.01 or 4.01 and you download the Chemscape Chime plug-in, you can view interactive 3-D structures of amino acids, proteins, and tRNA. Quizzes that challenge you to identify amino acids or protein structures are also available.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about rickets.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 10

• MIT Biology Hypertextbook: Review mutations by studying this section of the MIT Biology Hypertextbook.

• What were the genetic effects of radiation in the offspring of atomic bomb survivors? Find out by examining this report from the Radiation Effects Research Foundation.

• You can easily access specific information Gaucher disease, Marfan syndrome, myotonic dystrophy, and polycystic kidney disease through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about sickle cell anemia, fradile-X syndrome, Ehlers-Danlos syndrome, muscular dystrophy, and/or Huntington disease.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 11

• The Web Karyotyping Activity from The Biology Project will allow you to play the role of a cytogenetic technician.

• The New Web Karyotyping Activity from The Biology Project will help you learn about new methods and techniques for diagnosing chromosomal abnormalities.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about Down syndrome, Edward syndrome, Patau syndrome, Turner syndrome, Klinefelter syndrome, Jacobs syndrome, cri-du chat, and/or Alagille syndrome.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 12

• On-line DNA Fingerprinting Activity from The Biology Project provides you with a family study that illustrates the concepts and techniques behind the techniques of DNA fingerprinting.

• DNA Forensics Problem Set 1 and DNA Forensics Problem Set 2 from The Biology Project will help you learn about the techniques used to obtain a DNA fingerprint. In part two, you will learn how to interpret actual case results.

• The Interactive Genetic Drift and Natural Selection Model site simulates the effects of genetic drift and natural selection on allele frequencies for several different populations.

• You can easily access specific information about Ellis-van Creveld syndrome through the Human Gene Map Site.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 13

• The Interactive Genetic Drift and Natural Selection Model site simulates the effects of genetic drift and natural selection on allele frequencies for several different populations.

• You can easily access specific information about PKU through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about glucose-6 phosphate dehydrogenase deficiency, Tay-Sachs disease, and/or diabetes mellitus.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 14

• A Science Odyssey: You Try It from PBS Online has an interactive activity on human evolution.

• The Eugenics Archive provides on-line access to documents, articles, and other relevant materials from the eugenics movement in the United States. Set aside extra time to look at this extensive and interesting collection!

• The Human Behavior and Evolution Society home page provides readers with a newsletter, research updates, and links.

• You can easily access specific information about DiGeorge syndrome through the Human Gene Map Site.

Chapter 15

• You can find information about Rh incompatibility at this site on Rhesus Disease.

• A Description of Immune Deficiencies can be found at this site.

• You can easily access specific information about diabetes and SCID through the Human Gene Map Site.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 16

• Learn about misconceptions about hereditary cancer risk at this site focusing on Cancer Risk Assessment and Counseling.

• The National Cancer Institute provides a detailed site focusing on cancer: CancerNet. Additional information about cancer can be found at The Genetics of Cancer Site.

• You can easily access specific information about breast cancer, melanoma, lung carcinoma, retinoblastoma, and the p53 protein through the Human Gene Map Site.

• Online Mendelian Inheritance in Man is a searchable database of information on genetic diseases. Try searching for information about Wilms' tumor and/or Li-Frallmeni.

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

Chapter 19

• Learn more about the cloning efforts of the creators of Dolly at the Roslin Institute Home Page.

Chapter 20

• Learn more about preimplantation genetic testing with this Fact Sheet from the American Society for Reproductive Medicine.

• The Roslin Institute Home Page contains information about nuclear transfer, the technique used to clone dolly.

• Clones-R-Us: Looking for a company to create your next clone? Consider Dream Technologies International.

Chapter 21

• The National Center for Biotechnology Information site provides you with the tools needed for "data mining" on the web. At this site, you can compare gene and protein sequences using BLAST, explore the outline of the complete human genome sequence using GeneMap'99, compare DNA from human and mouse sources using Human-Mouse Homology Maps, and obtain human, rat, and mouse gene sequence information using LocusLink. Other resources are also available at this site, so don't be afraid to explore!

• Learn more about genomics with the Introduction to Human Genome Computing via the WWW tutorial.