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Molecular Biology 2nd Edition Robert F. Weaver | ||||||
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Molecular Biology 2nd Edition Robert F. Weaver | ||||||
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Chapter 11
- We already know that TAFII250 has histone acetyl transferase (HAT) and protein kinase activities. Now Pham and Sauer have shown that the Drosophila form of this general transcription factor also has ubiquitin-conjugating (ubc) activity that can couple ubiquitin to the linker histone, H1. This may result in degradation of H1, or at least changing its conformation to allow greater access by RNA polymerase II and therefore stimulation of transcription. (Pham, A.-D. and F. Sauer. 2000. Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila. Science 289:2357-60)
- There are about as many TATA-less promoters as TATA-box-containing promoters in Drosophila cells. A typical TATA-less promoter contains both an initiator and a downstream promoter element DPE. Willy et al. have discovered a basal transcription factor called DPE-specific transcription factor (DSTF) that activates DPE-containing promoters and inhibits TATA-box-containing promoters. (Willy, P.J., R. Kobayashi, and J.T. Kadonaga. 2000. A basal transcription factor that activates or represses transcription. Science 290:982-84)
- See entry #1 under Chapter 12
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