Chapter 20
- Johnson et al. have identified a new human DNA polymerase, polymerase (iota). This enzyme is very inaccurate and is the one that actually inserts nucleotides opposite a pyrimidine dimer or other severely distorting damage when polymerase fails to act. Then an enzyme is needed to extend the mispaired dimer, and that is the role of polymerase . Thus, it is not polymerase , but polymerase that is primarily responsible for mispairing during replication of pyrimidine dimers. (Johnson, R.E., M.T. Washington, L. Haracska, S. Prakash, and L. Prakash. 2000. Eukaryotic polymerases and act sequentially to bypass DNA lesions. Nature 406:1015-19)
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