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Molecular Biology 2nd Edition Robert F. Weaver | ||||||
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Chapter 21
- Glover and McHenry have analyzed the activity of the dimeric replisome. They find that the nonhydrolyzable ATP analog, ATP S allows dissociation and reinitiation only of the polymerase replicating the lagging strand. The polymerase replicating the leading strand does not dissociate. These findings show that the holoenzyme is an asymmetric dimer, with one monomer responsible for replicating each strand. (Glover, B.P. and C.S. McHenry. 2001. The DNA polymerase III holoenzyme: An asymmetric dimeric replicative complex with leading and lagging strand polymerases)
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