|
Molecular Biology 2nd Edition Robert F. Weaver | ||||||
|
|
Student Resources
|
||||||
|
|
|
 |
 |
|||
|
|
Molecular Biology 2nd Edition Robert F. Weaver | ||||||
|
|
Student Resources
|
||||||
|
|
|
|
|
|
|||
Chapter 22
- Meiotic recombination in yeast is initiated by double-strand break (DSB) formation. Borde et al. show that delays in meiotic DNA replication also delay DSB formation, and therefore delay meiotic recombination. This effect can be confined to a region of a chromosome by delaying DNA replication in that region. Thus, DSB formation appears to depend on a process intiated by DNA replication in that region of the chromosome. (Borde, V., A.S.H. Goldman, and M. Lichten. 2000. Direct coupling between Meiotic DNA replication and recombination initiation. Science 290:806-09)
- Hunter and Kleckner have discovered an intermediate between a double-strand break (DSB) and a double-Holiday junction in meiotic recombination in yeast. This is a single-end invasion (SEI), in which one DSB end has undergone strand exchange with its homolog. This finding suggests that the two ends of a DSB perform strand exchange in succession, presumably by distinct processes. (Hunter, N. and N. Kleckner. 2001. The single-end invasion: An asymmetric intermediate at the double-strand break to double-Holliday junction transition of meiotic recombination. Cell 106:59-70)
feedback form |
permissions |
international |
locate your campus rep |
request a review copy
Copyright ©2001 The McGraw-Hill Companies.
digital solutions |
publish with us |
customer service |
mhhe home
Any use is subject to the
Terms of Use and Privacy Policy.
McGraw-Hill Higher Education is one of the many fine businesses of the
The McGraw-Hill Companies.