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Chapter 18: Gene Technology


Additional Readings

Chapter 18: Gene Technology

Anderson, W. F.: "Gene Therapy," Scientific American, September 1995, pages 123–28. An update on the many clinical trials of gene therapy, involving several hundred patients.

Capecchi, M. R.: "Targeted Gene Replacement," Scientific American, vol. 270, March 1994, pages 52–59. Researchers at the University of Utah can change the nucleotide sequences of every single cell in a mouse. Can all genes be changed, or fixed?

Cohen, J. S., and M. E. Hogan: "The New Genetic Medicines," Scientific American, December 1994, pages 76–82. Can antisense and triplex agent DNA be used as "magic bullets" in combating cancer and deadly viral diseases?

Falk, B. W. and G. Bruening: "Will Transgenic Crops Generate New Viruses and New Diseases?" Science, vol. 263, March 11, 1994, pages 1395-96. A good, technical discussion of the risk-versus-benefit controversy in biotechnology.

Haseltine, W. A.: "Discovering Genes for New Medicines," Scientific American, March 1997, pages 92–97. An up-to-date look at some of the progress in gene technology.

Mullis, K.: "The Unusual Origin of the Polymerase Chain Reaction," Scientific American, April 1990, pages 56–65. How a critical advance in gene engineering technology was made.

Neufeld, P. J., and N. Colman: "When Science Takes the Stand," Scientific American, May 1990, pages 46–53. DNA and other evidence is increasingly applied to the solution of criminal cases but must be used with caution.

Stix, G.: "A Recombinant Feast: New Bioengineered Crops Move Toward Market," Scientific American, March 1995, pages 38–40. A progress report on the growing role of genetic engineering in modern agriculture.

Various authors: "The Human Genome Project," Science, vol. 265, September 30, 1994. An entire issue devoted to the Human Genome Project, including a spectacular wall chart of human chromosomes with all known loci labeled.

Various authors: "Making Gene Therapy Work," Scientific American, June 1997, pages 95–123. A special report on current gene therapy research, including its role in fighting cancer and AIDS.

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