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Chapter 13: DNA Replication And The Cell Cycle |
1. Relevance of Topic
Major secrets of the cell cycle have been unlocked: cloning of large whole organisms is now possible.
Cancer is a cell cycle control phenomenon.
Errors in DNA replication account for a large number of human genetic defects, not to mention defects in other organisms.
Current events include the fight against recently mutated bacteria that are spreading deadly disease in the human population.
2. Continuity
The previous sections on cell structure and function relate closely to this chapter on the details of cell replication.
Chapters to follow that cover inheritance and other topics in genetics, are best understood with a solid foundation in cell replication mechanisms.
Previous chapters on protein and polymer structure are easily related to sections of this chapter that deal with the structure of DNA and chromosomes.
3. Demonstration Activities
Text section 13.1
1. Show Figure 13.1 or some other picture of chromosomes in the condensed state.
2. Use computer-enhanced karyotypes showing banding patterns on chromosomes.
3. Show Figure 13.4 or some other illustration of DNA packaging, from the nucleotide level to the condensed chromosome state.
Text section 13.2
1. Figure 13.5 shows the chromosome with various parts of the morphology indicated.
2. Show Figure 13.4 or some other illustration of DNA packaging, from the nucleotide level to the condensed chromosome state.
Text section 13.3
1. Show Figures 13.6 and 13.7, and discuss the way in which the double-helix is replicated.
Text section 13.4
1. Show Figure 13.10 and discuss the mechanisms of replication.
Text section 13.6
1. Show Figures 13.11 and 13.12 or some other schematic of the cell cycle, with each phase sized according to the time the cell spends in it. Different colors for different phases are useful.
2. Show an EM of a cell dividing, to illustrate cytokinesis.
3. Show pictures of nerve and muscle cells, and discuss G0 and interphase in general.
Text section 13.7
1. Draw or show a drawing of the cell cycle and indicate where the checkpoints occur.
Text section 13.8
1. Show the text art of stages of mitosis, and include micrographs of dividing plant and animal cells (e.g. Allium root tip and whitefish blastula, respectively).
2. Show Figure 13.13 and discuss the spindle apparatus.
3. Show Figure 13.14 and discuss the kinetochore.
Text section 13.9
1. Show Figures 13.15 and 13.16 when discussing procaryotic cell division.
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