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Preparation of Amides
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Chapter 22:
Amines
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(review of Chapter 20)
Reaction type:
Nucleophilic Acyl Substitution
Summary
- Primary amines, R-NH2
and secondary amines, R2-NH undergo nucleophilic acyl substitution
with carboxylic acid derivatives to give amides.
- The most common examples
are the reactions of acid chlorides and anhydrides, though esters do react
with amines.