 |
|
 |
|
|
|
Substituent Effects (contd.)
The regioselectivity for further substitution of disubstituted benzenes can usually be predicted by looking at the cumulative effects of the substituents.
As a suggested method, look at each of the substituents, label their
directing effects, then indicate the sites where they would promote reactivity
with small arrows. Some issues that can arise are shown by the following
worked examples:
 |
 |