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Chapter 17: Aldehydes and Ketones. Nucleophilic Addition
to C=O
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Reactions of Primary Amine Derivatives
Reaction type: Nucleophilic Addition then Elimination
Summary
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Aldehydes and ketones react with a range of primary amine derivatives to
give substituted imines.
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The derivatives with ammonia are too unstable to be isolated but can be
reduced in situ to amines.
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The mechanism of these type of reactions is shown on the previous page.
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The reaction of 2,4-dinitrophenylhydrazone (2,4-DNP or Brady's reagent)
is used as a laboratory test for aldehydes and ketones since the products
precipitate as yellow to red solids.
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Yellow to red precipitate indicates a positive test result
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Related Reactions
