Chapter 20: Carboxylic Acid Derivatives. NucleophilicAcyl Substitution

Reactions for Interconverting Carboxylic Acids Derivatives

Here is a table that summarises the methods for interconverting carboxylic acid derivatives.  The more important reactions in emphasised in bold, and the reactions of the parent carboxylic acids (chapter19) in blue.
 
 

To make ->  From
	-	RCO2-	R'OH	H2O	R2NH	H2O, HO-
	-	-	R'OH	H2O	R2NH	H2O, HO-
	-	-	R'OH, heat H+ or B-	H2O, H3O+ heat	R2NH	H2O, HO- heat
	SOCl2    or PCl3	Heat, -H2O	R'OH, heat H+	-	R2NH heat	HO-
	-	-	-	H2O, H3O+ heat	-	H2O, HO- heat
	-	RCOCl	R'-Br or -I	H3O+	-	-