Chapter 21: Ester Enolates
Reactions of Active Methylene systems
There are 3 potentially important reactions of active methylenes (
what are they ?
)
Alkylation by alkyl halides
Conjugate addition to
a,b
-unsaturated carbonyls (Michael addition)
Loss of CO
2
(decarboxylation)
Alkylation
Michael addition
Decarboxylation