Chapter 27: Amino Acids, Peptides and Proteins
Nucleophilic substitution of
a
-halocarboxylic acids
Reaction type: Nucleophilic Substitution
Summary
Reagents excess ammonia.
This reaction is an example of a
nucleophilic substitution
with a halide as the leaving group.
The
a-
halocarboxylic acid can be obtained via an
a
-
substitution reaction
of a carboxylic acid (Hell-Volhard-Zelinsky reaction).
Question:
Why is an excess of ammonia required ?
Related Reactions
a-
Halogenation of Carboxylic Acids
Substitution Reactions of Alkyl Halides
Strecker synthesis
Alkylation of an acetamidomalonate
