The Phosphofructokinase-1 Reaction
In the reaction catalyzed by PFK-1, a the terminal phosphate of an ATP
is transferred to carbon #1 of a fructose-6-phsosphate
to produce fructose-1,6-bisphosphate and ADP. A different enzyme, PFK-2, transfers the phosphate to carbon #2 to produce F-2,6-bP, which is an allosteric activator of PFK-1. PFK-1 is subject to many other allosteric activators and inhibitors, and is a major regulatory enzyme of glycolysis.
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