The Phosphofructokinase-1 Reaction





In the reaction catalyzed by PFK-1, a the terminal phosphate of an ATP  is transferred to carbon #1 of a fructose-6-phsosphate  to produce fructose-1,6-bisphosphate and ADP.  A different enzyme, PFK-2, transfers the phosphate to carbon #2 to produce F-2,6-bP, which is an allosteric activator of PFK-1.  PFK-1 is subject to many other allosteric activators and inhibitors, and is a major regulatory enzyme of glycolysis.

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